21C Museum Hotel Louisville

700 West Main Street, Downtown Louisville, Louisville, United States - Show on map
4.5 1899 reviews

Located 1.5 miles from United States Marine Hospital, the 5-star 21C Museum Hotel Louisville is about 5 minutes' stroll from Kentucky Science Center. Boasting a location a few moments from Louisville Slugger Museum & Bat Factory, this hotel offers 96 rooms and a 24-hour bar onsite.

Location

Situated in the business Downtown Louisville district, the Louisville hotel is a mere 0.7 miles from Flame Run Glass Studio and Gallery. The historic boarding Thomas Edison House is also located around 25 minutes' walk from the non-smoking 21C Museum Hotel Louisville. This accommodation allows you to enjoy such natural sights as Falls of the Ohio State Park 2.5 miles away. There is Main / 7th bus stop right around the corner from the boutique hotel.

Rooms

A mini bar fridge, tea and coffee making equipment along with a flat-screen TV with satellite channels are provided in each of the allergy-friendly rooms at the 21C Museum Hotel Louisville. The rooms have elegant furniture featuring a writing desk.

Food & Drinks

Choose from an unlimited choice of American dishes at Main Eatery which is only steps away from the accommodation.

Leisure & Activities

21C Museum Hotel Louisville goes above and beyond to pamper guests, offering a Turkish steam bath and a sauna, along with healthcare professionals. This Louisville hotel provides guests with access to fitness classes in a gym area and a fitness studio. Business travelers will benefit from banquet facilities and a photocopier available at 17 meeting rooms on site.

Why choose 21C Museum Hotel Louisville

Select room

Main amenities

  • Wi-Fi

  • Parking

  • 24-hour services

  • Fitness/Gym

  • Spa and relaxation

  • On-site Dining

  • Meeting facilities

  • Child-friendly

  • Wheelchair access

  • Air conditioning

  • Pets

General
  • Wi-Fi
  • Parking
  • 24-hour services
  • Fitness/Gym
  • Spa and relaxation
  • On-site Dining
  • Meeting facilities
  • Child-friendly
  • Wheelchair access
  • Air conditioning
  • Pets
1/35

Internet

  • Wi-Fi

Parking options

  • Parking
  • Valet parking

Activities

  • Fitness centre
  • Yoga class

Property services

  • Safe deposit box
  • 24-hour reception
  • Security
  • Luggage storage
  • Locker room
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining options

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

In the kitchen

  • Cookware/ Kitchen utensils

Business facilities

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

For kids

  • Cots

Recreation

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries

Devices

  • Flat-screen TV

Design

  • Carpeted floor

General facilities

  • No smoking on site
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Pets

  • Pets allowed

Important information

Check-in:
from 16:00 until 23:59
Check-out:
until 11:00
  • Children and extra beds
  • Maximum capacity of extra beds in a room is 1.

Enter dates to see availability

From USD 209 per night
Check-in 17 Mar 2026
Check-out 18 Mar 2026
Guests 2 guests

Adults:

2

Children:

0
Special offers & deals Limited offer

Summer Deal

Up to 15% off
Make the most of summer with up to 15% off and free breakfast – limited-time offer.

Members Only Rate

Up to 15% off
Join now to unlock up to 15% off on your dates – visible to members only.

Mobile-Only Deal

An exclusive discount – get up to 10% off when you book from your phone.

Family Package Deal

Up to 20% off
Save up to 20% with special family packages that include your stay, meals, and fun for the kids..

Early Booking Discount

Up to 20% off
Save up to 20% when you book at least 30 days before your trip.

Rooms

Photos of 21C Museum Hotel Louisville

Location of 21C Museum Hotel Louisville

700 West Main Street, Downtown Louisville, Louisville, United States

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    Guest reviews of 21C Museum Hotel Louisville

    8.7 Fabulous
    186 reviews

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    100% Verified Reviews
    Enter dates to see availability
    From USD 209 per night
    Check-in 17 Mar 2026
    Check-out 18 Mar 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    Check-in & out
    17 Mar 2026
    18 Mar 2026
    Guests
    2 guests
    Contact Us
    21C Museum Hotel Louisville
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    Details:

    700 West Main Street, Louisville, United States

    Important information
    21C Museum Hotel Louisville
    Check-in:
    from 16:00 until 23:59
    Check-out:
    until 11:00
    • Children and extra beds
    • Maximum capacity of extra beds in a room is 1.