21C Museum Hotel Louisville

700 West Main Street, Downtown Louisville, Louisville, United States - Heart of Museum Row
4.5 1899 reviews

Positioned 2.5 miles from Falls of the Ohio State Park and approximately 5 minutes by foot from Frazier International History Museum, the 5-star 21C Museum Hotel Louisville provides a banquet hall for a variety of uses. Offering a Turkish steam bath and a sauna along with an American-style restaurant, the hotel boasts a central location a stone's throw from Kentucky Science Center.

Location

Centrally situated in the business Downtown Louisville district, the boutique-style hotel is within 600 feet of Louisville Slugger Museum & Bat Factory. Guests can easily reach KFC Yum Center Arena a short way from the 21C Museum Hotel Louisville. Guests will also appreciate the vicinity to Fort Nelson Park, located a mere 5 minutes' walk away. Along with other cultural attractions Muhammad Ali Center Museum is nestled 950 feet from the accommodation. Main / 7th bus stop is just around the corner from the 21C Museum Hotel.

Rooms

Staying at the Louisville hotel, you may choose from one of the 96 rooms featuring a flat-screen TV with satellite channels, as well as essentials such as air conditioning. Furnished with a writing desk, the rooms also have a mini bar fridge, tea and coffee making equipment. 21C Museum Hotel Louisville offers rooms with views of the town.

Food & Drinks

Proof On Main restaurant serves American cuisine for dinner. Guests can relax and have a snack in the 24-hour bar.

Leisure & Activities

This property provides guests with fitness classes, as well as access to a wellness area. With a golf course, guests can stay fit at the hotel. Finally, the 21C Museum Hotel Louisville houses a business center featuring banquet facilities and a photocopier.

Why choose 21C Museum Hotel Louisville

Select room
  • Immersive artist-designed rooms

  • Bourbon-focused dining experience

  • On-site contemporary art museum

  • 24-hour fitness center access

Main amenities

  • Wi-Fi

  • Parking

  • 24-hour services

  • Fitness/Gym

  • Spa and relaxation

  • On-site Dining

  • Meeting facilities

  • Child-friendly

  • Wheelchair access

  • Air conditioning

  • Pets

General
  • Wi-Fi
  • Parking
  • 24-hour services
  • Fitness/Gym
  • Spa and relaxation
  • On-site Dining
  • Meeting facilities
  • Child-friendly
  • Wheelchair access
  • Air conditioning
  • Pets
1/35

Internet

  • Wi-Fi

Parking options

  • Parking
  • Valet parking

Activities

  • Fitness centre
  • Yoga class

Property services

  • Safe deposit box
  • 24-hour reception
  • Security
  • Luggage storage
  • Locker room
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining options

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

In the kitchen

  • Cookware/ Kitchen utensils

Business facilities

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

For kids

  • Cots

Recreation

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries

Devices

  • Flat-screen TV

Design

  • Carpeted floor

General facilities

  • No smoking on site
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Pets

  • Pets allowed

Important information

Check-in:
from 16:00 until 23:59
Check-out:
until 11:00
  • Children and extra beds
  • Maximum capacity of extra beds in a room is 1.

Enter dates to see availability

From USD 209 per night
Check-in 1 May 2026
Check-out 2 May 2026
Guests 2 guests

Adults:

2

Children:

0
Special offers & deals Limited offer

Summer Deal

Up to 15% off
Make the most of summer with up to 15% off and free breakfast – limited-time offer.

Members Only Rate

Up to 15% off
Join now to unlock up to 15% off on your dates – visible to members only.

Mobile-Only Deal

An exclusive discount – get up to 10% off when you book from your phone.

Family Package Deal

Up to 20% off
Save up to 20% with special family packages that include your stay, meals, and fun for the kids..

Early Booking Discount

Up to 20% off
Save up to 20% when you book at least 30 days before your trip.

Rooms

Photos of 21C Museum Hotel Louisville

Location of 21C Museum Hotel Louisville

700 West Main Street, Downtown Louisville, Louisville, United States

 -  Heart of Museum Row
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    Guest reviews of 21C Museum Hotel Louisville

    8.8 Fabulous
    183 reviews

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    100% Verified Reviews
    Enter dates to see availability
    From USD 209 per night
    Check-in 1 May 2026
    Check-out 2 May 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    Check-in & out
    1 May 2026
    2 May 2026
    Guests
    2 guests
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    21C Museum Hotel Louisville
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    Details:

    700 West Main Street, Louisville, United States

    Important information
    21C Museum Hotel Louisville
    Check-in:
    from 16:00 until 23:59
    Check-out:
    until 11:00
    • Children and extra beds
    • Maximum capacity of extra beds in a room is 1.